WNT10B Polymorphism in Korean Stroke Patients with Yin Deficiency Pattern

Area of Science:

• Genetics
• Traditional Korean Medicine
• Neurology

Background:

• WNT10B is implicated in adipogenesis and obesity.
• Cerebral infarction (CI) is a significant health concern.
• Yin Deficiency is a pattern in Traditional Korean Medicine (TKM).

Purpose of the Study:

• To investigate the association between WNT10B gene polymorphism (G-607C) and the Yin Deficiency pattern in Korean elderly subjects with cerebral infarction.
• To explore the potential of WNT10B as a genetic marker for Yin Deficiency in stroke patients.

Main Methods:

• Genotyping of the WNT10B G-607C single nucleotide polymorphism (SNP) using TaqMan probe in 630 cerebral infarction patients.
• Validation of genotyping accuracy through direct sequencing in 5% of subjects.
• Statistical analysis using a multiple logistic regression model to assess genetic association.

Main Results:

• A significantly higher frequency of the CC genotype of WNT10B G-607C was observed in the Yin Deficiency pattern group (29.33%) compared to the Non-Yin Deficiency pattern group (23.96%).
• The association was statistically significant (P = 0.0339) with an odds ratio of 2.005 (1.054-3.814) in a recessive model.
• This is the first study to report a WNT10B polymorphism association with Yin Deficiency in a TKM context within a CI population.

Conclusions:

• The WNT10B G-607C polymorphism is associated with the Yin Deficiency pattern in elderly Korean cerebral infarction patients.
• This WNT10B variant may serve as a diagnostic genetic marker for Yin Deficiency in stroke patients.
• Findings support the development of personalized medical care strategies based on genetic profiles and TKM patterns.