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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Genetic Lingo01:11

Genetic Lingo

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Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
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Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice

Published on: July 11, 2025

HLA Immune Function Genes in Autism.

Anthony R Torres1, Jonna B Westover, Allen J Rosenspire

  • 1Center for Persons with Disabilities, Utah State University, 6804 Old Main Hill, Logan, UT 84322, USA.

Autism Research and Treatment
|August 29, 2012
PubMed
Summary
This summary is machine-generated.

Genetic variations in human leukocyte antigen (HLA) genes may contribute to autism etiology. Further investigation into these complex HLA regions is crucial for understanding autism

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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

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Last Updated: May 19, 2026

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
09:13

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Published on: July 11, 2025

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

Area of Science:

  • Immunogenetics
  • Neurodevelopmental Disorders
  • Human Genetics

Background:

  • Human leukocyte antigen (HLA) genes are critical for immune responses and linked to autoimmune diseases.
  • Autism spectrum disorder (ASD) shows associations with HLA genes, suggesting immune system dysregulation.
  • Existing genetic studies for autism have limited success, indicating the need for broader genomic interrogation.

Purpose of the Study:

  • To investigate the potential role of genetic polymorphisms within the human leukocyte antigen (HLA) region in the etiology of autism.
  • To explore the contribution of non-antigen-presenting HLA genes to autism development.

Main Methods:

  • Analysis of genetic polymorphisms in the HLA region, focusing on non-antigen-presenting areas.
  • Comparative genetic studies in autism subjects and control populations (details not provided in abstract).

Main Results:

  • Preliminary findings suggest associations between specific HLA gene polymorphisms and autism.
  • Non-antigen-presenting HLA regions may harbor genetic factors relevant to autism.

Conclusions:

  • Genetic variations in the HLA region, particularly non-antigen-presenting genes, are proposed as potential contributors to autism etiology in specific individuals.
  • Further research into the complex HLA region is warranted to fully understand its role in autism.