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[Experimental studies on VIP containing nerve in canine bladder neck].

T Fuse1

  • 1Department of Urology, Nihon University School of Medicine.

Nihon Hinyokika Gakkai Zasshi. the Japanese Journal of Urology
|December 1, 1990
PubMed
Summary

Vasoactive intestinal polypeptide (VIP) nerves significantly decrease bladder neck pressure after sacral nerve stimulation in dogs. This suggests VIP plays a key role in bladder neck opening via parasympathetic influence and smooth muscle relaxation.

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Area of Science:

  • Neuroscience
  • Urology
  • Physiology

Context:

  • Vasoactive intestinal polypeptide (VIP) is implicated as an inhibitory nerve in non-adrenergic, non-cholinergic pathways.
  • The precise role of VIP in bladder neck function requires further elucidation.

Purpose:

  • To investigate the functional role of VIP in the bladder neck.
  • To examine the effects of sacral nerve stimulation on bladder neck pressure and VIP nerve activity in canines.

Summary:

  • Electrical stimulation of sacral nerves in male dogs led to a significant decrease in bladder neck pressure, with no change in intravesical pressure.
  • Immunohistochemical analysis revealed increased VIP-positive nerve deposits in the bladder neck post-stimulation, absent in controls.
  • Acetylcholine esterase (AchE) staining showed no significant differences, indicating VIP's distinct role.

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Impact:

  • Demonstrates the presence of VIP-containing and parasympathetic nerves in the canine bladder neck.
  • Provides evidence that VIP contributes to bladder neck opening through smooth muscle relaxation mediated by parasympathetic nerves.