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Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...

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Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

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The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...

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Related Experiment Video

Updated: May 19, 2026

Mimicking and Manipulating Pancreatic Acinar-to-Ductal Metaplasia in 3-dimensional Cell Culture

Mimicking and Manipulating Pancreatic Acinar-to-Ductal Metaplasia in 3-dimensional Cell Culture

Published on: February 11, 2019

MicroRNAs in pancreas development.

O Dumortier¹, E Van Obberghen

¹Institute for Research on Cancer and Aging of Nice - CNRS UMR7284/INSERM U1081, Aging and Diabetes team, 06107 Nice, France.

Diabetes, Obesity & Metabolism

|August 30, 2012

Summary

This summary is machine-generated.

MicroRNAs (miRNAs) are key regulators of gene expression. This review explores how miRNAs impact pancreas development and beta-cell function.

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Published on: February 11, 2019

Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation

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Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Generation of Scaffold-free, Three-dimensional Insulin Expressing Pancreatoids from Mouse Pancreatic Progenitors In Vitro

Published on: June 2, 2018

Area of Science:

Developmental Biology
Molecular Biology
Genetics

Background:

Pancreas development involves complex morphogenesis, proliferation, and differentiation.
Gene expression control is crucial for pancreatic development.
MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.

Purpose of the Study:

To review the role of miRNAs in pancreas development.
To specifically examine the implications of miRNAs on beta-cell development and function.

Main Methods:

Literature review focusing on miRNA regulation in pancreas development.
Analysis of studies investigating miRNA targets and functions in pancreatic cells.

Main Results:

miRNAs are critical for fine-tuning gene expression during pancreas organogenesis.
Dysregulation of specific miRNAs can affect beta-cell differentiation and proliferation.
miRNAs influence multiple cellular processes essential for pancreas development.

Conclusions:

miRNAs are integral to the precise control of pancreas development.
Understanding miRNA roles is vital for addressing pancreatic diseases and improving beta-cell therapies.