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Updated: May 19, 2026
11:44
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
Published on: March 30, 2019
Cyclin-dependent kinase modulators and cancer therapy
Marialucia Gallorini1, Amelia Cataldi, Viviana di Giacomo
1Department of Pharmacy, University G. dAnnunzio, Chieti-Pescara, Italy.
Summary
Cell cycle checkpoints regulate cell division. This review details cyclin-dependent kinases (CDKs) and four drugs (alvocidib, P276-00, SNS-032, seliciclib) that modulate CDK activity to control cancer cell proliferation.
Area of Science:
- Molecular Biology
- Cell Biology
- Pharmacology
Background:
- Cell cycle control is crucial for eukaryotic cell life, with checkpoints ensuring proper progression.
- Cyclin-dependent kinases (CDKs) and cyclins are key regulators, often overexpressed in cancer cells, driving uncontrolled proliferation.
Purpose of the Study:
- To review CDK-cyclin complexes in cell cycle phases.
- To analyze molecular mechanisms of CDK activation and inhibition.
- To report on four novel CDK-modulating drugs in clinical trials for cancer treatment.
Main Methods:
- Literature review of CDK-cyclin interactions and cell cycle regulation.
- Analysis of molecular pathways governing CDK activation and inhibition.
- Compilation and review of clinical trial data for alvocidib, P276-00, SNS-032, and seliciclib.
Main Results:
- CDK-cyclin complexes play distinct roles in different cell cycle phases.
- Specific molecular mechanisms control CDK activity, offering therapeutic targets.
- Four CDK modulators show potential in clinical trials for various cancers.
Conclusions:
- Modulating CDK activity is a promising strategy to inhibit cancer cell proliferation.
- The reviewed drugs represent potential new therapeutic agents for cancer treatment.
- Further research and clinical evaluation are warranted for these CDK inhibitors.
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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
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Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
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To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.