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NK cells inhibit T-bet-deficient, autoreactive Th17 cells

W Wu1, S Shi, H-G Ljunggren

  • 1Department of Neurology and Tianjin Neurologic Institute, Tianjin Medical University General Hospital, Tianjin, China.

Scandinavian Journal of Immunology
|August 30, 2012
PubMed
Summary

Natural killer (NK) cells regulate T helper 17 (Th17) cell responses. In T-bet-deficient mice lacking NK cells, autoreactive Th17 cells increase, but wild-type NK cells restore normal Th17 regulation via IFN-γ.

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