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Published on: May 27, 2015
Anti-inflammatory and anti-allergic effect of Agaricus blazei extract in bone marrow-derived mast cells
Hyuk-Hwan Song1, Hee-Sung Chae, Sei-Ryang Oh
1Immune Modulator Research Center, Bio-Therapeutics Research Institute, Korea Research Institute of Bioscience and Biotechnology, ChungBuk, Korea.
Abstract:
In this study, the anti-inflammatory and anti-allergic effects of the chloroform-soluble extract of Agaricus blazei in mouse bone marrow-derived mast cells (BMMCs) were investigated. The chloroform-soluble extract inhibited IL-6 production in PMA plus A23187-stimulated BMMCs, and down-regulated the phosphorylation of Akt. In addition, this extract demonstrated inhibition of the degranulation of β-hexosaminidase and the production of IL-6, prostaglandin D(2) and leukotriene C(4) in PMA plus A23187-induced BMMCs. In conclusion, the chloroform-soluble extract of Agaricus blazei exerted anti-inflammatory and anti-allergic activities mediated by influencing IL-6, prostaglandin D(2), leukotriene C(4), and the phosphorylation of Akt.
