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Asthma-IV: Diagnostic and Management

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Related Experiment Video

Updated: May 19, 2026

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

How to diagnose and phenotype asthma.

Parameswaran Nair¹, Angira Dasgupta, Christopher E Brightling

¹Department of Medicine, St Joseph's Healthcare, McMaster University, 50 Charlton Avenue East, Hamilton, Ontario L8N4A6, Canada. parames@mcmaster.ca

Clinics in Chest Medicine

|August 30, 2012

Summary

Asthma diagnosis and treatment can be improved by identifying specific patient phenotypes. Understanding cellular inflammation and imaging helps tailor therapies for better asthma management.

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Last Updated: May 19, 2026

Murine Model of Allergen Induced Asthma

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Published on: May 14, 2012

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Published on: July 22, 2025

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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Area of Science:

Pulmonology and Respiratory Medicine
Immunology
Medical Imaging

Background:

Asthma is a chronic airway disease defined by variable airflow obstruction, hyperresponsiveness, and inflammation.
Current asthma management strategies benefit from precise patient stratification.
Understanding the underlying inflammatory processes is key to effective treatment.

Purpose of the Study:

To review current diagnostic and phenotyping approaches for asthma.
To emphasize phenotyping based on cellular inflammation and radiological imaging.
To explore how these phenotypes can guide current and future asthma therapies.

Main Methods:

Literature review focusing on asthma diagnosis, phenotyping, and treatment strategies.
Analysis of studies correlating cellular inflammation patterns with asthma severity.
Evaluation of the role of radiological imaging in identifying asthma phenotypes.

Main Results:

Phenotyping asthma based on cellular inflammation reveals distinct subtypes.
Radiological imaging provides objective markers for asthma phenotyping.
Personalized treatment approaches informed by phenotype show promise.

Conclusions:

Asthma phenotyping using cellular inflammation and imaging is crucial for targeted therapy.
Future research should focus on developing and validating phenotype-specific treatments.
This approach could lead to more effective and individualized asthma care.