Related Experiment Video
Updated: May 19, 2026

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
Published on: August 23, 2022
Gastrointestinal perforations in neonatal period: experience over 10 years
George Sakellaris1, Nikolaos Partalis, Olga Dede
1Department of Paediatric Surgery, University Hospital of Heraklion, Crete, Greece. g.sakell@med.uoc.gr
Aim:
This report describes our experience concerning gastrointestinal perforation due to necrotizing enterocolitis during a 10-year period.
Method:
The cases of 27 gastrointestinal perforations, which were treated in our hospital, were retrospectively reviewed.
Results:
All patients were neonates and infants up to the age of 2 months. The study population consisted of 16 boys (59.3%) and 11 girls (40.7%). Twenty-one neonates (77.8%) were preterm, and the median gestational age was 28 weeks. Twenty-four cases (88.9%) of perforation underwent laparotomy. The overall mortality was 63%. Seventy-six percent of the preterm neonates and only 16.7% of the full-term neonates died.
Conclusions:
Gastrointestinal perforation is still connected with a high mortality rate, with necrotizing enterocolitis being the main cause of death. The neonates who did not undergo surgery all died.
Related Concept Videos
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus.
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Intestinal Obstruction II: Pathophysiology
