Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Ongoing advancements in the research of radiation- induced toxicity and the development of interventions to protect and/or mitigate its effects.

Frontiers in public health·2024
Same author

Effect of Age at Time of Irradiation, Sex, Genetic Diversity, and Granulopoietic Cytokine Radiomitigation on Lifespan and Lymphoma Development in Murine H-ARS Survivors.

Radiation research·2024
Same author

Where are the medical countermeasures against the ARS and DEARE? A current topic relative to an animal model research platform, radiation exposure context, the acute and delayed effects of acute exposure, and the FDA animal rule.

International journal of radiation biology·2023
Same author

Age and Sex Divergence in Hematopoietic Radiosensitivity in Aged Mouse Models of the Hematopoietic Acute Radiation Syndrome.

Radiation research·2022
Same author

Semi-Supervised Segmentation of Radiation-Induced Pulmonary Fibrosis From Lung CT Scans With Multi-Scale Guided Dense Attention.

IEEE transactions on medical imaging·2021
Same author

Animal Models: A Non-human Primate and Rodent Animal Model Research Platform, Natural History, and Biomarkers to Predict Clinical Outcome.

Health physics·2021

Related Experiment Video

Updated: May 19, 2026

Computer-Generated Animal Model Stimuli
26:43

Computer-Generated Animal Model Stimuli

Published on: July 29, 2007

The MCART Consortium animal models series.

Thomas J MacVittie1

  • 1Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, MD, USA. tmacvittie@som.umaryland.edu

Health Physics
|August 30, 2012
PubMed
Summary

The Medical Countermeasures Against Radiological Threats (MCART) consortium develops treatments for acute radiation syndrome (ARS) and delayed radiation effects. Validated animal models are crucial for FDA approval of these medical countermeasures (MCM).

More Related Videos

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models
09:18

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models

Published on: February 3, 2026

Hand-Rearing Method for Infant Marmosets
04:52

Hand-Rearing Method for Infant Marmosets

Published on: June 9, 2023

Related Experiment Videos

Last Updated: May 19, 2026

Computer-Generated Animal Model Stimuli
26:43

Computer-Generated Animal Model Stimuli

Published on: July 29, 2007

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models
09:18

Multianimal Magnetic Resonance Imaging for Tumor Measurements in Pancreatic Cancer Mouse Models

Published on: February 3, 2026

Hand-Rearing Method for Infant Marmosets
04:52

Hand-Rearing Method for Infant Marmosets

Published on: June 9, 2023

Area of Science:

  • Radiation Countermeasures
  • Toxicology
  • Regulatory Science

Background:

  • The National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Medical Countermeasures Against Radiological Threats (MCART) consortium aims to develop medical countermeasures (MCM).
  • These MCM target the sequelae of acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE).
  • A parallel objective involves evaluating decorporating agents to reduce internalized radionuclide burdens.

Discussion:

  • Development of MCM must adhere to the U.S. Food and Drug Administration's (FDA) "animal rule" (AR).
  • This regulatory pathway necessitates validated animal models to demonstrate efficacy for MCM intended for radiation exposure.
  • The FDA guidance emphasizes essential elements for animal models in MCM efficacy demonstration.

Key Insights:

  • Validated animal models are paramount for the regulatory approval of MCM.
  • Efficacy of MCM must be demonstrated under conditions simulating lethal radiation doses.
  • The MCART consortium focuses on critical sequelae of ARS and DEARE.

Outlook:

  • Advancing the development and licensure of MCM for radiation emergencies.
  • Ensuring preparedness for radiological threats through robust countermeasure strategies.
  • Facilitating regulatory pathways for novel MCM through rigorous scientific validation.