Is the extracellular matrix an integral and dynamic component of the sodium and water homeostatic system?

This hypothesis questions the validity of Starling's hypothesis regarding the distribution of water and electrolytes between the intravascular and interstitial compartments. It emphasises the potential importance of the gel state of the extracellular matrix in determining interstitial compliance and the distribution of water and electrolytes between the intravascular and interstitial compartments. Because the physicochemical properties of the extracellular matrix can change rapidly in response to numerous stimuli, it is suggested that the extracellular matrix is an integral and dynamic component of the sodium homeostatic system.