Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperlipidaemia and atherogenesis.

A D Williams

    Medical Hypotheses
    |November 1, 1990
    PubMed
    Summary
    This summary is machine-generated.

    Hyperlipidaemia is often a normal response to injury, not a cause of heart disease. Focusing on hyperlipidaemia alone risks inappropriate treatment for conditions like atherosclerosis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The antibody-peptide fusion protein, AT-02, is an effective opsonin with pan-amyloid reactivity.

    npj drug discovery·2026
    Same author

    Ophthalmic Miscellany.

    Medical examiner (Chicago, Ill.)·2023
    Same author

    Ophthalmic Notes-Cases from Practice.

    Medical examiner (Chicago, Ill.)·2023
    Same author

    Muscæ Volitantes.

    Hall's journal of health·2022
    Same author

    Acute Myringitis-Atropine in Its Treatment.

    The Southern medical record·2022
    Same author

    Orthodontia.

    The Dental register·2021
    Same journal

    Calcitonin Gene-Related Peptide-Induced Central Sensitization: A Hypothesis for Long COVID Symptoms.

    Medical hypotheses·2026
    Same journal

    Subclinical mastitis during lactation: a modifiable risk factor for breast cancer?

    Medical hypotheses·2025
    Same journal

    The Role of Hemispheric Sensory Shifts: Impacts on Stretch Reflex and Motor Plasticity Post-Stroke.

    Medical hypotheses·2025
    Same journal

    Neuron-Targeted Exosome Therapy: A Novel Approach for Treating Cardiogenic Dementia via RyR2 Inhibition.

    Medical hypotheses·2025
    Same journal

    How the Somatosensory System Adapts to the Motor Change in Stroke: A Hemispheric Shift?

    Medical hypotheses·2024
    Same journal

    Unstable Plaque is a Treatable Cause of Cognitive Decline.

    Medical hypotheses·2024
    See all related articles

    Area of Science:

    • Cardiovascular Science
    • Metabolic Disorders
    • Pathophysiology

    Background:

    • Hyperlipidaemia is widely considered a primary cause of coronary artery atherosclerosis and myocardial infarction.
    • However, this perspective may overlook its role as a physiological response to underlying pathological processes.

    Purpose of the Study:

    • To challenge the conventional view of hyperlipidaemia as a direct cause of arterial disease.
    • To propose a hypothesis where hyperlipidaemia is a normal homeostatic response and a risk indicator, not a causative agent.

    Main Methods:

    • Review and synthesis of existing literature on hyperlipidaemia, atherosclerosis, and myocardial infarction.
    • Development of a new hypothesis integrating vessel wall injury, stress, and lipid metabolism.

    Related Experiment Videos

    Main Results:

    • The study suggests that for most individuals, hyperlipidaemia is a normal physiological response to other diseases, particularly those involving vessel wall injury.
    • Abnormal vessel wall movement, potentially stress-induced, may trigger this response.
    • Hyperlipidaemia is proposed as a risk indicator rather than a direct cause of arterial disease.

    Conclusions:

    • Hyperlipidaemia should not be viewed as a direct cause of myocardial infarction, as this can lead to ineffective treatments.
    • Treatments aimed at lowering cholesterol and low-density lipoproteins (LDL) without addressing the root cause are compared to treating pneumonia symptoms without addressing the infection.