Related Experiment Video
Updated: May 19, 2026
14:23
Isolation of Embryonic Tissues and Formation of Quail-Chicken Chimeric Organs Using The Thymus Example
Published on: February 16, 2019
Comprehensive timeline of mesodermal development in the quail small intestine
Rebecca T Thomason1, David M Bader, Nichelle I Winters
1Department of Cell and Developmental Biology, Vanderbilt University, Nashville, Tennessee.
Summary
This study details the morphological changes in avian intestinal mesoderm development, providing a timeline of key events for researchers studying gut formation.
Area of Science:
- Developmental Biology
- Gastroenterology
- Cell Biology
Background:
- Intestinal development involves complex morphogenetic events of splanchnic mesoderm diversification into multiple tissue layers.
- A lack of detailed morphological descriptions hinders research into intestinal mesoderm development.
Purpose of the Study:
- To establish a comprehensive timeline of avian intestinal mesodermal development.
- To identify structural relationships between mesodermal components during intestinal morphogenesis.
Main Methods:
- Utilized immunofluorescence and morphometric analyses in quail embryos.
- Examined wild-type and Tg(tie1:H2B-eYFP) transgenic embryos.
- Tracked key developmental features from intestinal primordium to definitive structure.
Main Results:
- Detailed the timeline of radial compartment formation, basement membrane dynamics, and mesothelial differentiation.
- Documented mesenchymal expansion, smooth muscle differentiation, and vascular maturation.
- Identified temporal structural relationships among developing intestinal mesodermal components.
Conclusions:
- Presents a roadmap for evaluating experimental data on intestinal development.
- Integrates diverse data within the longitudinal context of intestinal morphogenesis.
- Aids investigators and clinicians in understanding intestinal development.
More Related Videos
09:03Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation
Published on: February 7, 2012
06:46Mouse Fetal Whole Intestine Culture System for Ex Vivo Manipulation of Signaling Pathways and Three-dimensional Live Imaging of Villus Development
Published on: September 4, 2014
Related Concept Videos
01:56Gastrulation
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
01:23Renewal of Intestinal Stem Cells
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
01:27Histology of the Small Intestine
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
01:15Small Intestine
The small intestine is primarily responsible for digestion and nutrient absorption. It spans from the pyloric sphincter to the ileocecal valve and connects to the large intestine.
The small intestine is divided into three main sections - the duodenum, jejunum, and ileum. The duodenum, approximately 25 cm long, is nearest the stomach. It acts as a 'mixing bowl,' where chyme (partially digested food) blends with digestive enzymes from the pancreas and liver. The duodenum's unique C-shape wraps...
The small intestine is divided into three main sections - the duodenum, jejunum, and ileum. The duodenum, approximately 25 cm long, is nearest the stomach. It acts as a 'mixing bowl,' where chyme (partially digested food) blends with digestive enzymes from the pancreas and liver. The duodenum's unique C-shape wraps...
01:15Development of the Lymphatic System
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
01:23Anatomy of the Intestines
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...