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Correlation analysis between plasma D-dimer levels and orthopedic trauma severity.

Li-Dan Zhang1, Hong-Bo Liu, Yu-Neng Li

  • 1Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital, Beijing 100035, China.

Chinese Medical Journal
|August 31, 2012
PubMed
Summary

Plasma D-dimer levels are significantly elevated in acute trauma patients and closely correlate with the number of fractures. This indicates D-dimer is a valuable indicator of trauma severity.

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Area of Science:

  • Orthopedic Trauma Research
  • Biomarker Analysis
  • Clinical Diagnostics

Background:

  • The relationship between plasma D-dimer levels and deep vein thrombosis remains inconclusive in existing literature.
  • Orthopedic trauma presents complex diagnostic challenges, necessitating reliable indicators of injury severity.

Purpose of the Study:

  • To investigate the correlation between plasma D-dimer levels and the severity of orthopedic trauma.
  • To evaluate D-dimer as a potential biomarker for acute trauma assessment.

Main Methods:

  • Retrospective analysis of orthopedic trauma cases, comparing acute and non-acute trauma patient groups.
  • Measurement and comparison of plasma D-dimer levels between patient cohorts.
  • Statistical analysis to determine the relationship between D-dimer levels and trauma severity, including the number of fractures.

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Main Results:

  • Plasma D-dimer levels were significantly higher in the acute trauma group (548 cases) compared to the non-acute trauma group (501 cases) (P < 0.01).
  • A strong positive linear correlation (r = 0.9532) was observed between plasma D-dimer levels and the number of fractures in acute trauma patients.

Conclusions:

  • Elevated plasma D-dimer is a common finding in trauma patients.
  • Plasma D-dimer levels demonstrate a close correlation with the number of fractures, serving as an indicator of trauma severity.
  • D-dimer is a valuable biomarker not only for diagnosing deep vein thrombosis and pulmonary embolism but also for assessing the severity of acute orthopedic trauma.