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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: May 19, 2026

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
07:56

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

Neonatal stroke.

M A Rutherford1, L A Ramenghi, F M Cowan

  • 1Imaging Sciences Department, Imperial College and MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK. m.rutherford@imperial.ac.uk

Archives of Disease in Childhood. Fetal and Neonatal Edition
|August 31, 2012
PubMed
Summary
This summary is machine-generated.

Neonatal stroke, often caused by arterial infarction or cerebral sinus venous thrombosis (CSVT), affects over 50% of children with neurodevelopmental issues. Anticoagulation is recommended for CSVT but requires careful monitoring.

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A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
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A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

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Last Updated: May 19, 2026

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Published on: April 21, 2017

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

Area of Science:

  • Neurology
  • Pediatrics
  • Neonatal Medicine

Background:

  • Neonatal stroke involves ischemic or hemorrhagic brain injuries in newborns.
  • Common causes include arterial infarction (e.g., middle cerebral artery) and cerebral sinus venous thrombosis (CSVT).
  • Both conditions have multifactorial origins, with high incidence of thrombophilic disorders in mothers and infants.

Purpose of the Study:

  • To review focal brain injuries in neonates.
  • To discuss arterial infarction and CSVT as primary causes.
  • To highlight the multifactorial origins and neurodevelopmental outcomes.

Main Methods:

  • Literature review focusing on neonatal stroke.
  • Analysis of etiological factors, including thrombophilia.
  • Examination of neurodevelopmental morbidity and therapeutic interventions.

Main Results:

  • Focal brain injury in neonates frequently results from arterial infarction or CSVT.
  • Thrombophilic disorders are common but rarely the sole cause.
  • Over 50% of affected children experience neurodevelopmental morbidity.

Conclusions:

  • Neonatal stroke has significant long-term consequences for child development.
  • Early identification and management of risk factors are crucial.
  • Anticoagulation therapy for CSVT requires careful consideration, especially with hemorrhage.