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[B-cell-directed therapy in patients with connective tissue diseases]

A M Jacobi1, T Dörner

  • 1Sektion Rheumatologie und Klinische Immunologie/ Innere Medizin D, Universitätsklinikum Münster. annett.jacobi@ukmuenster.de

Deutsche Medizinische Wochenschrift (1946)
|August 31, 2012
PubMed

B cells are able to present antigen, secrete cytokines and differentiate into (auto)antibody secreting cells and are therefore considered as an important therapeutic target in patients with autoantibody-mediated autoimmune disease. Benefits and limitations of B-cell-directed therapies and unmet medical needs are discussed in this minireview. B cell targeting broadens our armamentarium available to treat SLE and other connective tissue diseases. But further research addressing unmet medical needs is required and refractory patients receiving B cell-directed off-label therapeutics should be enrolled in registries to collect information on the value and safety of these drugs in rare autoimmune diseases.

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