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Updated: May 19, 2026

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Published on: June 14, 2016
[SAM not only in hypertrophic cardiomyopathy]
Anna Klisiewicz1, Agnieszka Lech, Jacek Różański
1Klinika Wad Wrodzonych Serca, Instytut Kardiologii, Warszawa-Anin. aklisiewicz@ikard.pl
This case report highlights that severe left ventricular outflow tract obstruction (LVOTO) can occur via systolic anterior movement (SAM) in patients without hypertrophic cardiomyopathy. Hypovolemia and a hyperdynamic state from increased catecholamines can precipitate dynamic LVOTO.
Area of Science:
- Cardiology
- Physiology
Background:
- Left ventricular outflow tract obstruction (LVOTO) is commonly caused by hypertrophic obstructive cardiomyopathy (HOCM) leading to systolic anterior movement (SAM).
- Other conditions like dehydration, vasodilatation, and pheochromocytoma have also been linked to LVOTO.
Observation:
- A case of severe LVOTO with SAM mechanism is presented in a patient without hypertrophic cardiomyopathy.
- The patient experienced hypovolemia and a hyperdynamic state due to elevated catecholamines.
Findings:
- Dynamic LVOTO can develop in the absence of significant septal hypertrophy.
- The combination of hypovolemia and a hyperdynamic state is a critical factor in precipitating dynamic LVOTO via SAM.
Implications:
- This case broadens the understanding of potential causes for dynamic LVOTO.
- Clinicians should consider hypovolemia and hyperdynamic states in the differential diagnosis of LVOTO, even without HOCM.
- Recognizing these factors is crucial for timely diagnosis and management of dynamic LVOTO.
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