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Isolation, Processing and Analysis of Murine Gingival Cells
Published on: July 2, 2013
Periostin is down-regulated during periodontal inflammation
M Padial-Molina1, S L Volk, A D Taut
1Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, 1011 North University Ave., Office 3349, Ann Arbor, MI 48109-1078, USA.
Journal of Dental Research
|August 31, 2012
Summary
Chronic periodontal inflammation significantly reduces tissue periostin levels, a key protein for periodontal ligament integrity. This decrease correlates with increased alveolar bone loss in disease progression.
Area of Science:
- Biomedical Science
- Oral Biology
- Periodontology
Background:
- Periostin is a matricellular protein vital for maintaining periodontal ligament integrity.
- Periodontal diseases compromise periodontal integrity, but the role of periostin in this process is not fully understood.
Purpose of the Study:
- To investigate the impact of chronic periodontal inflammation on tissue periostin levels.
- To determine the correlation between periostin levels and periodontal breakdown.
Main Methods:
- A pre-clinical ligature-induced periodontal inflammatory disease model was used.
- Periodontal tissue specimens were analyzed using histology, immunofluorescence, and micro-CT.
- Statistical analyses included Kruskal-Wallis, Mann-Whitney, and Spearman's tests.
Main Results:
- Periostin levels significantly decreased over time during chronic inflammation (p < 0.001).
- Alveolar bone loss progressively increased from baseline to 4 weeks (p < 0.001).
- A significant inverse correlation was observed between periostin levels and alveolar bone loss (ρ = -0.545; p < 0.001).
Conclusions:
- Chronic periodontal inflammation leads to a significant reduction in periostin levels within the periodontal ligament.
- Decreased periostin levels are strongly associated with the progression of periodontal tissue damage and bone loss.
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