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Updated: May 19, 2026

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
[Effects of calcium and vitamin D supplementations on cardiovascular disease: review article]
1Unité d'épidémiologie populationnelle, Département de médecine communautaire, de premier recours et des urgences, HUG, 1211 Genève 14. idris.guessous@hcuge.ch
Insights
Calcium and vitamin D supplements show mixed effects on cardiovascular health. While calcium may lower blood pressure, it might increase heart attack risk, and evidence for vitamin D
Area of Science:
- Cardiovascular disease research
- Nutritional science
- Public health
Abstract:
Studies exploring the effect of calcium supplementation on cardiovascular risk suggest that systolic blood pressure decreases with supplementation. A lower calcium intake has been associated with an increased risk of stroke. By contrast, calcium supplementation may increase the risk of myocardial infarction. The effect of vitamin D supplementation on blood pressure is still unclear and no effect of vitamin D supplementation on coronary heart disease or stroke has been clearly demonstrated. There is a lack of randomized clinical trials primarily addressing the effect of these parameters on CVD. Currently, the use of calcium and vitamin D supplementations for the prevention of cardiovascular disease is not justified.
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