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Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage
William W Turner1, Karsten Hartvigsen, Agnes Boullier
1Department of Chemistry, Indiana University, Bloomington, Indiana 47405-7102, USA.
Abstract:
Macrophage scavenger receptors appear to play a major role in the clearance of oxidized phospholipid (OxPL) products. Discrete peptide-phospholipid conjugates with the phosphatidylcholine headgroup have been shown to exhibit binding affinity for these receptors. We report the preparation of a water-soluble, stable peptide-phospholipid conjugate (9) that possesses the necessary physical properties to enable more detailed study of the role(s) of OxPL in metabolic disease.
