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Related Concept Videos

Replication in Prokaryotes01:32

Replication in Prokaryotes

DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to the single origin of replication (ori) on the cell's circular chromosome. Replication then proceeds around the entire circle of the chromosome in each direction from the two replication forks, resulting in two DNA molecules.
Many Proteins Work Together to Replicate the Chromosome
Replication is coordinated and carried out by a host of specialized...
Replication in Prokaryotes02:35

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Replication in Prokaryotes02:35

Replication in Prokaryotes

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Binary Fission01:26

Binary Fission

Binary fission is the primary mode of asexual reproduction in prokaryotes, such as bacteria. It results in the production of two genetically identical daughter cells. This highly efficient process ensures the rapid propagation of bacterial populations under favorable conditions and involves coordinated cellular and molecular events.DNA Replication and SeparationThe process begins with the replication of the bacterial chromosome. The circular DNA molecule unwinds at a specific origin of...
Binary Fission01:20

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Fission is the division of a single entity into two or more parts, which regenerate into separate entities that resemble the original. Organisms in the Archaea and Bacteria domains reproduce using binary fission, in which a parent cell splits into two parts that can each grow to the size of the original parent cell. This asexual method of reproduction produces cells that are all genetically identical.
Chromosome Replication02:31

Chromosome Replication

Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin of...

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Related Experiment Video

Updated: May 19, 2026

Determination of the Optimal Chromosomal Location(s) for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach
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Determination of the Optimal Chromosomal Location(s) for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach

Published on: September 11, 2017

Chromosome replication and segregation in bacteria.

Rodrigo Reyes-Lamothe1, Emilien Nicolas, David J Sherratt

  • 1Department of Biochemistry, University of Oxford, OX1 3QU, Oxford, United Kingdom. rodrigo.reyes@bioch.ox.ac.uk

Annual Review of Genetics
|September 1, 2012
PubMed
Summary
This summary is machine-generated.

Bacterial chromosome and plasmid duplication requires coordination with cell division. This study compares strategies for accurate duplication and segregation, focusing on ATP-binding proteins involved in bacterial chromosome segregation.

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Area of Science:

  • Cellular biology
  • Microbiology
  • Genetics

Background:

  • Cellular division requires precise chromosome duplication and segregation.
  • Bacterial replication elongation mechanisms are understood, but initiation control remains complex.
  • Unlike eukaryotes, bacteria often segregate replicated DNA before cell division.

Purpose of the Study:

  • To compare bacterial chromosome and plasmid duplication and segregation strategies.
  • To explore the coordination of replication with cell growth and division.
  • To review the roles of conserved ATP-binding proteins in bacterial chromosome segregation.

Main Methods:

  • Comparative analysis of chromosome and plasmid segregation.
  • Review of existing literature on bacterial DNA replication and segregation.
  • Examination of conserved ATP-binding protein families.

Main Results:

  • Bacterial chromosomes and plasmids employ distinct strategies for duplication and segregation.
  • Replication and segregation are tightly coordinated with cell growth and division in bacteria.
  • Three conserved ATP-binding protein families play crucial roles in chromosome segregation across diverse bacteria.

Conclusions:

  • Understanding bacterial DNA replication and segregation is key to cell cycle control.
  • ATP-binding proteins are essential for faithful chromosome segregation in bacteria.
  • Further research into these conserved proteins can reveal inter-relationships and mechanisms in various bacterial species.