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Yersinia pestis and approaches to targeting its outer protein H protein-tyrosine phosphatase (YopH)

M Bahta1, T R Burke

  • 1Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, U.S.A.

Current Medicinal Chemistry
|September 1, 2012
PubMed

Insights

Plague, a deadly infectious disease caused by Yersinia pestis, remains a global threat. This review explores developing inhibitors for YopH, a key Y. pestis virulence factor, for new anti-plague treatments.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biochemistry

Background:

  • Plague, a high-mortality infectious disease caused by Yersinia pestis (Y. pestis), has historically impacted human societies and remains an ongoing global health concern.
  • Y. pestis poses a significant threat due to its potential as a bioterrorism agent and its continued endemic presence worldwide.
  • The bacterium Yersinia pestis utilizes several virulence factors to establish infection, including the protein-tyrosine phosphatase, YopH.

Observation:

  • YopH is a critical virulence factor essential for Y. pestis pathogenesis.
  • Inhibiting YopH function could be a viable strategy to combat Y. pestis infections.
  • Understanding YopH's role is crucial for developing targeted anti-plague therapies.

Findings:

  • This review summarizes current knowledge on plague and its historical impact.
  • It details various strategies being explored for the development of YopH inhibitors.
  • The focus is on targeting YopH as a potential therapeutic approach against Y. pestis.

Implications:

  • Developing YopH inhibitors could lead to novel treatments for plague.
  • Effective anti-plague agents are needed to address both endemic disease and bioterrorism threats.
  • Targeting YopH offers a promising avenue for new drug discovery against Yersinia pestis infections.

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