Related Experiment Video

Updated: May 19, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

Contribution of morphine and morphine-6-glucuronide to respiratory depression in a child

J A Hannam1, B J Anderson

  • 1Department of Anaesthesiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. j.hannam@auckland.ac.nz

Anaesthesia and Intensive Care
|September 1, 2012
PubMed

Insights

Morphine-6-glucuronide, a metabolite of morphine, can cause delayed respiratory depression in patients with end-stage renal disease. Alternative analgesics like fentanyl are recommended for pain management in these patients.

Area of Science:

  • Pharmacology
  • Nephrology
  • Critical Care Medicine

Background:

  • The relationship between morphine plasma concentration and respiratory rate is established in adults and children.
  • The pharmacokinetic and pharmacodynamic profile of morphine-6-glucuronide (M6G), a key morphine metabolite, regarding respiratory effects remains unclear, particularly in renally impaired patients.

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