Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

iPS Cell Differentiation

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.

EPS and iPS Cells in Disease Research

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Global, regional and national intake of plant-based foods among youth in 185 countries (1990-2018): findings from the Global Dietary Database.

BMJ global health·2026

Same author

Editorial: Bioengineering and biotechnology approaches in cardiovascular sciences, volume III.

Frontiers in bioengineering and biotechnology·2026

Same author

Electro-activation driven self-dispersion of PdCuAg nanoparticles for high-performance formic acid oxidation.

Chemical communications (Cambridge, England)·2026

Same author

Retraction notice to 'Sam68 impedes the recovery of arterial injury by augmenting inflammatory response' [Journal of Molecular and Cellular Cardiology 137 (2019) 82-92].

Journal of molecular and cellular cardiology·2026

Same author

Trace Ru-Doped PtCuRu@PtRu Core-Shell Electrocatalyst for CO-Resilient Methanol Oxidation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

The therapeutic potential of epimedium and its bioactive flavonoids in hepatitis and cirrhosis: an integrative review.

Frontiers in cellular and infection microbiology·2026

Search research articles

Related Experiment Video

Updated: May 19, 2026

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

Induced pluripotent stem cells and their potential for basic and clinical sciences.

Lei Ye¹, Cory Swingen, Jianyi Zhang

¹Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA. ylei@umn.edu

Current Cardiology Reviews

|September 1, 2012

Summary

This summary is machine-generated.

Induced pluripotent stem (iPS) cells, derived from adult cells, offer therapeutic potential. This review covers iPS cell reprogramming, disease modeling, and clinical challenges for future treatments.

More Related Videos

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Published on: January 19, 2020

Related Experiment Videos

Last Updated: May 19, 2026

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Scalable 96-well Plate Based iPSC Culture and Production Using a Robotic Liquid Handling System

Published on: May 14, 2015

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Isolation of Adult Human Dermal Fibroblasts from Abdominal Skin and Generation of Induced Pluripotent Stem Cells Using a Non-Integrating Method

Published on: January 19, 2020

Area of Science:

Stem Cell Biology
Regenerative Medicine
Genetics

Background:

Adult somatic cells can be reprogrammed into induced pluripotent stem (iPS) cells.
iPS cells share characteristics with embryonic stem (ES) cells.
Reprogramming involves the induction of specific genes and factors.

Purpose of the Study:

To review recent advancements in iPS cell reprogramming techniques.
To explore the application of patient-specific iPS cells as disease models.
To analyze the clinical considerations and challenges of iPS cell-based therapies.

Main Methods:

Literature review of iPS cell reprogramming.
Analysis of iPS cell applications in disease modeling.
Discussion of clinical perspectives for iPS cell therapy.

Main Results:

Significant progress has been made in iPS cell reprogramming efficiency and safety.
Patient-specific iPS cells provide valuable models for studying genetic diseases.
iPS cell therapy holds promise but faces hurdles in clinical translation.

Conclusions:

iPS cells represent a powerful tool for regenerative medicine and disease research.
Further research is needed to overcome challenges in clinical applications.
iPS cell technology is advancing towards personalized therapeutic strategies.