[SAG-S solution--a new medium for the resuspension of erythrocyte concentrates]

Concentrates of erythrocytes without buffy coat, re-suspended in a newly developed electrolyte-containing re-suspension solution (SAG-S) poor in saccharose (30 mmol/l) are in vitro compared with commercial CDS-AG RCC. In the equivalence of biochemical parameters complex-haematological indicators show a significantly improved maintenance of the cell integrity in the new preparation of blood constituents up to a storage time of 35 days. By means of an in-vitro-technique we calculated for these SAG-S-erythrocytes a post-transfusional survival rate of 74%. In contrast to this the in-vivo survival rate for 20-day-old CDS-AG-cells was only 65% In the practically equivalent content of erythrocytes the preparations differ as to their purity. The saccharose concentration of 200 mmol/l presented in the CDS-AG medium has, as it is made evident, a stabilizing effect on the leukocytes, i.e. it is retarding the time-dependent WBC-destruction. The results of the clinical test step III confirm a good tolerability of the SAG-S RCC. By lacking possibilities of the comparison of equivalent (produced under the same preparation and storage conditions) concentrates of erythrocytes the higher transfusion efficiency of the SAG-S concentrates of erythrocytes to be expected could not be verified.