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Published on: June 10, 2025
Urinary ketone is associated with the heart failure severity
Ji Hyung Chung1, Jin-Sup Kim, Oh Yoen Kim
1Cardiovascular Product Evaluation Center, Cardiovascular Research Institute, Yonsei University Health System, Seoul, Republic of Korea.
Clinical Biochemistry
|September 1, 2012
Summary
Urinary ketone bodies are linked to heart failure severity. Higher ketone levels correlate with worse echocardiographic measurements, indicating potential biomarkers for heart failure progression.
Area of Science:
- Cardiology
- Metabolomics
- Biomarker Discovery
Background:
- Heart failure (HF) diagnosis and severity assessment rely on clinical and echocardiographic parameters.
- Identifying novel biomarkers for HF severity is crucial for improved patient management.
Purpose of the Study:
- To investigate the association between urinary metabolites and echocardiographic measurements in patients with systolic heart failure.
- To determine if urinary metabolite profiles correlate with the severity of heart failure.
Main Methods:
- A cohort of 46 patients with systolic HF and 32 controls underwent echocardiography.
- Urinary metabolites were quantified, excluding patients with type 2 diabetes mellitus.
- Statistical analyses, including multiple linear regression, were performed to identify associations.
Main Results:
- HF patients exhibited significantly different urinary levels of acetate, acetone, cytosine, methylmalonate, phenylacetylglycine, and 1-methylnicotinamide compared to controls.
- Urinary ketone levels, including acetoacetate and acetone, varied significantly with New York Heart Association (NYHA) classification.
- Urinary ketones independently predicted left ventricular ejection fraction and E/E' ratio.
Conclusions:
- Urinary ketone bodies are significantly associated with echocardiographic parameters indicative of heart failure severity.
- These findings suggest that urinary ketones may serve as potential biomarkers for assessing HF magnitude and progression.
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