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Updated: May 19, 2026
03:23
Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
Published on: May 10, 2024
Novel targeted therapies for eosinophilic disorders
Michael E Wechsler1, Patricia C Fulkerson, Bruce S Bochner
1Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA. mikewechsler@gmail.com
The Journal of Allergy and Clinical Immunology
|September 1, 2012
Summary
Hypereosinophilic syndromes (HESs) are chronic disorders causing significant health issues. This review explores eosinophil biology and potential new drug targets for treating HESs.
Area of Science:
- Hematology
- Immunology
- Pharmacology
Background:
- Hypereosinophilic syndromes (HESs) are a group of chronic disorders.
- Clinical manifestations are linked to eosinophilia and tissue infiltration.
- HESs are associated with considerable morbidity and mortality.
Purpose of the Study:
- To review eosinophil biology, focusing on pharmacotherapy targets.
- To summarize current and investigational eosinophil-targeting agents for HESs.
Main Methods:
- Literature review of eosinophil biology.
- Summary of pharmacologic agents targeting eosinophils.
- Analysis of agents in development, clinical trials, or approved for other conditions.
Main Results:
- Eosinophil biology presents multiple potential pharmacotherapy targets.
- Several agents targeting eosinophils are in various stages of development and clinical evaluation.
- Existing treatments like imatinib offer benefits but improved therapies are needed.
Conclusions:
- Targeting eosinophil biology offers promising therapeutic avenues for HESs.
- Further research and development of novel agents are crucial for improved patient outcomes.
- A comprehensive understanding of eosinophil-targeting agents is essential for managing HESs.
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