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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Related Experiment Video

Updated: May 19, 2026

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment
08:25

A Rat Graft Rejection Model of Intestinal Transplantation with Exteriorized Ileostomy for Longitudinal Prognosis Assessment

Published on: June 10, 2025

Intestinal transplantation: a review.

Chirag Sureshchandra Desai1, Khalid Mahmood Khan, Raffaele Girlanda

  • 1Georgetown Transplant Institute, Main Hospital Building, Washington, DC 20007, USA. csdesai@gmail.com

Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology
|September 1, 2012
PubMed
Summary

Intestinal transplantation offers a life-saving option for patients with intestinal failure unresponsive to parenteral nutrition. Outcomes vary, with isolated intestinal transplants showing better short-term survival than multivisceral transplants.

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Last Updated: May 19, 2026

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Area of Science:

  • Gastroenterology
  • Transplant Surgery
  • Hepatology

Background:

  • Parenteral nutrition is crucial for intestinal failure but can lead to complications.
  • Intestinal transplantation is an established treatment for patients with complications or failed rehabilitation.
  • Liver disease associated with parenteral nutrition often necessitates a multivisceral transplant.

Purpose of the Study:

  • To review the outcomes and prognostic factors of intestinal transplantation.
  • To compare isolated intestinal transplants with multivisceral transplants.
  • To discuss the role of intestinal transplantation in managing intestinal failure.

Main Methods:

  • Review of existing literature on intestinal transplantation outcomes.
  • Analysis of survival rates for isolated intestinal and multivisceral transplants.
  • Identification of factors influencing short-term and long-term transplant success.

Main Results:

  • Isolated intestinal transplants in adults show >80% 1-year survival.
  • Multivisceral transplants, common in infants, have <70% 1-year survival.
  • Poor prognostic factors include pre-transplant hospitalization and donor age >40; sepsis and rejection impact early outcomes.

Conclusions:

  • Intestinal transplantation provides survival and quality-of-life benefits for select patients with intestinal failure.
  • While outcomes are improving, long-term results for multivisceral transplants lag behind other abdominal organs.
  • Retransplantation outcomes are poor due to immunological challenges and patient frailty.