Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fetal Circulation01:14

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Transcytosis of IgG01:15

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
Physiological Barriers01:25

Physiological Barriers

Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bacterial Nanocellulose Hydrogels as a Next-Generation Biomaterial for Cardiac and Vascular Tissue Engineering: Structural, Biological, and Translational Perspectives.

Gels (Basel, Switzerland)·2026
Same author

Developmental plasticity of the placenta in the caviomorph rodent Microcavia australis.

Placenta·2026
Same author

From Toxin to Therapy: Biomedical Applications of Bee Venom in Cancer, Diabetes, and Neurodegenerative Disorders.

International journal of molecular sciences·2026
Same author

Decellularized Rat Lung Extracellular Matrix as an In Vitro Platform for Canine Yolk Sac-Derived Endothelial Precursor Cells for Pulmonary Endothelium Reconstruction Studies.

Bioengineering (Basel, Switzerland)·2026
Same author

Uterine Vulnerability to Environmental PM<sub>2.5</sub>: Chronic Wood Smoke Exposure Alters Morphogenesis Before First Pregnancy.

International journal of molecular sciences·2026
Same author

Extracellular vesicles in stem cell-based gonadal regeneration: mechanisms, therapeutic potential, and translational challenges.

Frontiers in veterinary science·2026

Related Experiment Video

Updated: May 19, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Iron transportation across the placenta.

Claudia M de Oliveira1, Marcio N Rodrigues, Maria Angélica Miglino

  • 1Pós-Graduação de Anatomia dos Animais Domésticos e Silvestres, FMVZ, Universidade de São Paulo, Brasil.

Anais Da Academia Brasileira De Ciencias
|September 1, 2012
PubMed
Summary

Iron transfer to fetuses occurs through various placental absorption methods, including direct contact and erythrocyte phagocytosis. This review explores these pathways and proposes new study approaches for nutrient transfer.

More Related Videos

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
08:08

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

Published on: June 18, 2013

Ex Vivo Perfusion of the Rodent Placenta
06:54

Ex Vivo Perfusion of the Rodent Placenta

Published on: May 30, 2019

Related Experiment Videos

Last Updated: May 19, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
08:45

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
08:08

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model

Published on: June 18, 2013

Ex Vivo Perfusion of the Rodent Placenta
06:54

Ex Vivo Perfusion of the Rodent Placenta

Published on: May 30, 2019

Area of Science:

  • Comparative placental physiology
  • Maternal-fetal nutrient transfer mechanisms

Background:

  • Iron is crucial for fetal development and survival.
  • Placental iron transfer varies significantly across animal species.
  • Existing knowledge on specific iron absorption pathways remains incomplete.

Purpose of the Study:

  • To review and synthesize current understanding of placental iron transfer mechanisms in animals.
  • To investigate the role of erythrophagocytosis in iron transport.
  • To propose novel methodologies for studying nutrient transfer across the placenta.

Main Methods:

  • Comprehensive literature survey on placental anatomy and function.
  • Analysis of documented iron absorption routes: transferrin-mediated, erythrocyte absorption, and glandular secretions.
  • Examination of erythrophagocytosis in maternal-fetal interfaces.

Main Results:

  • Identified four primary modes of placental iron transfer: direct transferrin absorption, erythrocyte phagocytosis, absorption from endometrial gland secretions, and extravasated blood phagocytosis.
  • Highlighted the significance of erythrophagocytosis in species like bovines, small ruminants, canines, and felines.
  • Noted that the precise function of erythrophagocytosis is undefined in several species.

Conclusions:

  • Placental iron transfer is complex, involving multiple pathways.
  • Erythrophagocytosis is a potentially significant route for iron delivery to the fetus.
  • Further research employing new methods is needed to fully elucidate placental nutrient transfer.