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The intestinal phase of digestion is the third and final stage of the digestive process, occurring after the cephalic and gastric phases. It begins when chyme, a partially digested mixture of food and digestive enzymes, enters the small intestine from the stomach. This phase is crucial for nutrient absorption and involves complex hormonal and enzymatic interactions.
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Trophic effects of continuous infusion of [Leu15]-gastrin-17 in the rat.

B Ryberg1, J Axelson, R Håkanson

  • 1Department of Biology AB Hässle, Gastrointestinal Research, Mölndal, Sweden.

Gastroenterology
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Exogenous gastrin administration in rats led to increased stomach weight and oxyntic mucosal mass. This study highlights gastrin

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Area of Science:

  • Gastroenterology
  • Endocrinology
  • Physiology

Background:

  • Gastrin is a key hormone regulating gastric acid secretion and mucosal growth.
  • Understanding gastrin's trophic effects is crucial for managing gastrointestinal disorders.

Purpose of the Study:

  • To investigate the trophic effects of exogenous gastrin on the digestive tract and pancreas.
  • To examine the impact of gastrin on enterochromaffin-like (ECL) cell density in the gastric oxyntic mucosa.

Main Methods:

  • Female rats received continuous subcutaneous infusion of synthetic human [Leu15]-gastrin-17 for 28 days.
  • Two dosage groups (1.2 or 2.4 nmol/kg.h) were compared to a control group.
  • Measurements included plasma gastrin levels, stomach weight, oxyntic mucosal mass, ECL cell density, histamine concentration, and histidine decarboxylase activity.

Main Results:

  • Exogenous gastrin significantly increased plasma gastrin levels in a dose-dependent manner.
  • Gastrin administration resulted in increased stomach weight and oxyntic mucosal mass.
  • ECL cell density, histamine concentration, and histidine decarboxylase activity were elevated in the oxyntic mucosa, while other digestive organs showed no significant changes.

Conclusions:

  • Continuous exogenous gastrin infusion induces trophic changes in the rat stomach, specifically increasing mucosal mass and ECL cell parameters.
  • These findings mimic the effects of hypergastrinemia caused by acid secretion inhibitors.
  • Gastrin's primary trophic influence appears localized to the gastric oxyntic mucosa.