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Effect of hepatitis B virus infection on right and left ventricular functions

Mehmet Demir1, Canan Demir

  • 1Department of Cardiology, Bursa Yuksek Ihtisas Education and Research Hospital, Bursa, Turkey. drmehmetmd@gmail.com

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|September 1, 2012
PubMed

Insights

Hepatitis B virus (HBV) infection is linked to impaired right ventricular systolic function. This study found reduced RV function and elevated pulmonary artery pressure in HBV patients, suggesting potential cardiac complications.

Area of Science:

  • Cardiology
  • Hepatology
  • Infectious Diseases

Background:

  • Hepatitis B virus (HBV) infection affects millions globally.
  • Cardiac involvement in HBV patients is not fully understood.
  • Right and left ventricular functions are crucial for cardiovascular health.

Purpose of the Study:

  • To investigate right and left ventricular systolic functions in patients with hepatitis B virus (HBV) infection.
  • To compare cardiac parameters between HBV patients and a healthy control group.

Main Methods:

  • The study included 50 HBsAg-positive patients and 50 healthy controls.
  • Transthoracic echocardiography was used to assess cardiac function.
  • Key right and left ventricular systolic parameters were measured and compared.

Main Results:

  • HBV patients exhibited significantly lower right ventricular fractional area change (RV FAC), tricuspid annular plane excursion (TAPSE), and RV myocardial systolic velocity (St).
  • Right atrium and right ventricle diameters were enlarged in HBV patients.
  • Patients with HBV showed elevated systolic pulmonary artery pressure compared to controls.

Conclusions:

  • Hepatitis B virus infection is associated with right ventricular systolic dysfunction.
  • HBV infection may lead to the development of pulmonary hypertension.
Abstract

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