Adult mesenchymal stem cells explored in the dental field

Area of Science:

• Regenerative Medicine
• Dental Engineering
• Stem Cell Biology

Background:

• Stem cell-based therapies offer significant therapeutic potential for diverse conditions, including neurodegenerative diseases and tissue repair.
• The ability of stem cells to regenerate and repair damaged tissues has led to the discovery of multiple stem/progenitor cell types.
• Adult multipotent mesenchymal stem cells (MSCs) are under investigation for periodontal regeneration and tooth engineering.

Purpose of the Study:

• To review and discuss the potential of various adult multipotent mesenchymal stem cells (MSCs) for regenerative purposes in the dental field.
• To highlight the application of different MSC sources in periodontal regeneration and tooth engineering.

Main Methods:

• Literature review of current research on stem cell applications in dentistry.
• Identification and categorization of various adult multipotent mesenchymal stem cells relevant to dental regeneration.
• Discussion of the therapeutic potential of these stem cells in periodontal regeneration and tooth engineering.

Main Results:

• Multiple types of adult multipotent mesenchymal stem cells (MSCs) are being investigated for dental applications.
• Sources include bone marrow, adipose tissue, dental pulp, dental follicle, exfoliated deciduous teeth, apical papilla, periodontal ligament, alveolar bone, and gingiva.
• These MSCs show promise as precursors for regenerative therapies in dentistry.

Conclusions:

• Various adult multipotent mesenchymal stem cells (MSCs) hold significant potential for periodontal regeneration and tooth engineering.
• Further research into these MSCs can advance regenerative medicine in dentistry.
• The diverse sources of MSCs offer promising avenues for developing novel dental therapies.