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Updated: May 19, 2026

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Synthesis and Characterization of Supramolecular Colloids
Published on: April 22, 2016
One-pot synthesis of spheres-on-sphere silica particles from a single precursor for fast HPLC with low back pressure
Adham Ahmed1, Harald Ritchie, Peter Myers
1Department of Chemistry, University of Liverpool, Liverpool, UK.
Advanced Materials (Deerfield Beach, Fla.)
|September 1, 2012
Abstract:
Spheres-on-sphere (SOS) silica particles are prepared in a one-pot scalable synthesis from mercaptopropyltrimethoxysilane with hydrophilic polymer and cationic surfactant under alkaline conditions. The SOS particles exhibit solid-core porous-shell properties. The fast separation of small molecules and proteins with low back pressure are demonstrated by high-performance liquid chromatography (HPLC) for the columns packed with SOS-particles.
