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Polymorphism M55V in gene encoding small ubiquitin-like modifier 4 (SUMO4) protein associates with susceptibility to

Song-Tao Tang1, Wen-Jia Peng, Chang-Jiang Wang

  • 1Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Diabetes/Metabolism Research and Reviews
|September 1, 2012
PubMed
Abstract

Insights

This meta-analysis found that the small ubiquitin-like modifier 4 (SUMO4) M55V gene polymorphism is significantly associated with type 1 diabetes mellitus (T1DM) in both Asian and Caucasian populations. The study also confirmed its association with type 2 diabetes mellitus (T2DM) in Asians.

Area of Science:

  • Genetics
  • Immunology
  • Endocrinology

Background:

  • The small ubiquitin-like modifier 4 (SUMO4) gene is implicated in various cellular processes.
  • Polymorphisms in the SUMO4 gene have been investigated for their potential role in diabetes mellitus susceptibility.
  • Previous studies have yielded conflicting results regarding the association between SUMO4 gene polymorphism and type 1 (T1DM) or type 2 diabetes mellitus (T2DM).

Purpose of the Study:

  • To conduct a comprehensive meta-analysis evaluating the association between SUMO4 gene polymorphism and susceptibility to T1DM and T2DM.
  • To consolidate evidence from existing studies to provide a more robust assessment of the SUMO4-diabetes link.

Main Methods:

  • A systematic meta-analysis was performed on published case-control studies available before August 2011.
  • The SUMO4 M55V polymorphism was specifically examined for its association with T1DM and T2DM.
  • Statistical analysis included fixed/random effect models to calculate combined odds ratios (OR) and 95% confidence intervals (95% CI) for various genotype and allele comparisons.

Main Results:

  • Sixteen studies comprising 9190 T1DM cases and 10,456 controls were analyzed.
  • A significant association was found between the SUMO4 M55V polymorphism (A allele vs. G allele) and T1DM in both Asian (OR=0.79, P=0.000) and Caucasian (OR=0.84, P=0.007) populations.
  • For T2DM, which included only Asian patients, a significant association with the SUMO4 M55V polymorphism (A allele vs. G allele) was also detected (OR=0.86, P=0.001).

Conclusions:

  • The SUMO4 M55V polymorphism is significantly associated with an increased susceptibility to T1DM in both Asian and Caucasian individuals.
  • The SUMO4 M55V polymorphism is also significantly associated with T2DM susceptibility, particularly in the Asian population.
  • These findings highlight the role of SUMO4 gene variations in the pathogenesis of diabetes mellitus across different ethnic groups.

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