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Related Experiment Video

Updated: May 19, 2026

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Kidney stones and kidney function loss: a cohort study.

R Todd Alexander¹, Brenda R Hemmelgarn, Natasha Wiebe

¹7-129 Clinical Science Building, University of Alberta, 8440 112 Street, Edmonton, Alberta T6B 2G3, Canada.

BMJ (Clinical Research Ed.)

|September 1, 2012

Summary

Kidney stones significantly increase the risk of developing end-stage renal disease (ESRD) and chronic kidney disease. While the absolute risk increase is small, even one stone episode elevates adverse renal outcomes.

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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Area of Science:

Nephrology
Epidemiology
Public Health

Background:

Kidney stones are a common condition.
The long-term renal consequences of kidney stones are not fully understood.
Investigating the association between kidney stones and adverse renal outcomes is crucial for patient management and public health.

Purpose of the Study:

To determine if kidney stones increase the risk of end-stage renal disease (ESRD).
To assess the association between kidney stones and other adverse renal outcomes, including chronic kidney disease and doubling of serum creatinine.
To evaluate the impact of kidney stones on renal health in a large adult population.

Main Methods:

A registry cohort study was conducted using validated algorithms from claims and facility utilization data.
The study included 3,089,194 adult patients in Alberta, Canada, from 1997 to 2009, excluding those with baseline ESRD or pyelonephritis.
Outcomes assessed included incident ESRD, stage 3b-5 chronic kidney disease, and sustained doubling of serum creatinine, with a median follow-up of 11 years.

Main Results:

A total of 23,706 patients (0.8%) experienced at least one kidney stone episode.
Kidney stones were associated with a significantly increased risk of ESRD (aHR 2.16), new stage 3b-5 chronic kidney disease (aHR 1.74), and doubling of serum creatinine (aHR 1.94).
The excess risk appeared greater in women and younger individuals (<50 years), though significant in all strata. Absolute risk increases were small.

Conclusions:

Even a single kidney stone episode is linked to a significant increase in the likelihood of adverse renal outcomes, including ESRD.
The absolute increase in adverse renal outcomes associated with kidney stones is small.
These findings highlight the importance of monitoring renal health in patients with a history of kidney stones.