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Updated: May 19, 2026
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Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
Gamma knife radiosurgery for mesial temporal lobe epilepsy
John D Rolston1, Mark Quigg, Nicholas M Barbaro
1Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA.
Epilepsy Research and Treatment
|September 1, 2012
Summary
Gamma Knife radiosurgery offers a promising, noninvasive alternative for patients with refractory mesial temporal lobe epilepsy. Evidence suggests it provides outcomes comparable to surgical resection, with ongoing trials to confirm efficacy.
Area of Science:
- Neurology
- Neurosurgery
- Radiation Oncology
Background:
- Mesial temporal lobe epilepsy (MTLE) often persists despite medical management.
- Surgical resection is an option but carries significant risks.
- Gamma Knife radiosurgery (GKRS) is being explored as a less invasive alternative.
Purpose of the Study:
- To evaluate GKRS as a potential alternative to open surgery for refractory MTLE.
- To compare the efficacy and safety of GKRS with surgical resection.
Main Methods:
- Review of accumulated evidence from multiple studies comparing GKRS and surgical resection.
- Ongoing Radiosurgery or Open Surgery for Epilepsy (ROSE) trial, a randomized controlled trial.
Main Results:
- Existing evidence indicates radiosurgery outcomes are comparable to surgical resection.
- The ROSE trial is actively investigating this comparison.
Conclusions:
- GKRS is a viable and promising alternative treatment for refractory MTLE.
- Further investigation and trials are crucial to establish GKRS as a standard therapy.
