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Parietal lobes in schizophrenia: do they matter?
Murat Yildiz1, Stefan J Borgwardt, Gregor E Berger
1Department of Neurology, Cantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland.
Schizophrenia Research and Treatment
|September 1, 2012
Summary
Schizophrenia may originate with parietal lobe (PL) alterations. Early structural and functional changes in the PL could progress to frontal regions in emerging schizophrenia cases.
Area of Science:
- Neuroscience
- Psychiatry
- Radiology
Background:
- Abnormal parietal lobe (PL) function is linked to psychotic-like experiences.
- The precise role of the PL in schizophrenia remains incompletely understood.
Purpose of the Study:
- To investigate the specific role of the parietal lobe in the pathophysiology of schizophrenia.
Main Methods:
- A comprehensive literature search of Medline databases was conducted.
- Keywords included: parietal lobe, schizophrenia, lesions, epilepsy, cognition, genetic disorders, MRI, fMRI, PET, and SPECT.
- References from relevant studies were cross-checked.
Main Results:
- Childhood-onset schizophrenia imaging studies suggest grey matter abnormalities initiate in parietal and occipital lobes, advancing to frontal regions.
- While findings are not entirely consistent, some studies indicate early PL changes in individuals at risk for schizophrenia.
Conclusions:
- A hypothesis is proposed that structural and functional alterations may initiate in the PL for some individuals with emerging schizophrenia.
- These initial PL changes could potentially progress to affect frontal regions over time.
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