Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Pulmonary Tuberculosis III

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integration of Gene Expression and Digital Histology to Predict Treatment-Specific Responses in Breast Cancer.

medRxiv : the preprint server for health sciences·2025

Same author

Prognostic and molecular multi-platform analysis of CALGB 40603 (Alliance) and public triple-negative breast cancer datasets.

NPJ breast cancer·2025

Same author

Urine-free response criteria predict progression-free survival in multiple myeloma: a post hoc analysis of BMT CTN 0702.

Leukemia·2025

Same author

Minimal Residual Disease Status in Multiple Myeloma 1 Year After Autologous Hematopoietic Cell Transplantation and Lenalidomide Maintenance Are Associated With Long-Term Overall Survival.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2024

Same author

Phase 1 Study of Bortezomib, Fludarabine, and Melphalan, With or Without Total Marrow Irradiation, as Allogeneic Hematopoietic Stem Cell Transplant Conditioning for High-risk or Relapsed/Refractory Multiple Myeloma.

American journal of clinical oncology·2024

Same author

Impact of Obstetric Emergency High-Fidelity Simulation on Maternity Nurses' Self-Efficacy in the Rural Hospital Setting.

MCN. The American journal of maternal child nursing·2023

Same journal

Case of Myelodysplastic Syndrome 15 Years After Kidney Transplantation Under Long-Term Immunosuppression.

Case reports in hematology·2026

Same journal

Extranodal Nasal Type NK/T-Cell Lymphoma of the Transverse Colon With Gastrointestinal Perforation in a 15-Year-Old: Durable Remission With Modified SMILE Chemotherapy and HSCT.

Case reports in hematology·2026

Same journal

Unmasking Evans Syndrome: A Case of New Onset Anemia and Thrombocytopenia in a Pregnant Patient With Systemic Lupus Erythematosus.

Case reports in hematology·2026

Same journal

Molecular Relapse After a Second Treatment-Free Remission Attempt Following Asciminib in Chronic Myeloid Leukemia: A Case Report.

Case reports in hematology·2026

Same journal

Common Clonal Origin of Core-Binding-Factor AML in Both Donor and Recipient Following Kidney Transplantation.

Case reports in hematology·2026

Same journal

T-Cell Lymphoma With Sarcoid-Like Reaction and Secondary Myelofibrosis: A Unique Case Report and Literature Review.

Case reports in hematology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 19, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Diffuse large B-cell lymphoma with calf muscle localization.

Laura Bourdeanu¹, Rashmi Menon, George Somlo

¹Department of Medical Oncology and Experimental Therapeutics, City of Hope Comprehensive Cancer Center, 1500 E Duarte Road, Duarte, CA 91010, USA.

Case Reports in Hematology

|September 1, 2012

Summary

This summary is machine-generated.

This study details a rare case of diffuse large B-cell lymphoma (DLBCL) manifesting uniquely in a patient's calf muscle. The patient achieved a complete response, highlighting potential treatment success for this uncommon presentation.

Related Experiment Videos

Last Updated: May 19, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

Area of Science:

Oncology
Hematology
Pathology

Background:

Diffuse large B-cell lymphoma (DLBCL) commonly affects lymph nodes but frequently presents with extranodal involvement (30-40%).
Extranodal sites include the intestine, bone, breast, liver, skin, lung, and central nervous system.
Muscle involvement by DLBCL is exceptionally rare, accounting for only 0.5% of extranodal non-Hodgkin lymphoma (NHL).

Observation:

A unique case of extranodal DLBCL was observed in a 72-year-old male patient.
The lymphoma predominantly involved the gastrocnemius muscle in the calf.
This presentation represents an unusual site for DLBCL manifestation.

Findings:

The patient presented with DLBCL localized to the calf muscle.
Following diagnosis and treatment, the patient achieved a complete response.
The patient remained free of local recurrence or distant metastasis post-treatment.

Implications:

This case underscores the diverse extranodal manifestations of DLBCL.
It highlights the possibility of successful treatment outcomes even in rare muscle-specific presentations.
Further research into the behavior and management of extranodal DLBCL in unique sites is warranted.