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Updated: May 19, 2026

Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier

Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier

Published on: April 5, 2017

CNS intravascular lymphoma: a case report.

Amer Awad¹, Bachir Estephan, Olaf Stüve

¹Baton Rouge Neurology Associates, Baton Rouge General Medical Center, 3600 Florida Boulevard, Baton Rouge, LA 70806, USA.

Case Reports in Neurological Medicine

|September 1, 2012

Summary

Intravascular lymphoma, a rare condition, can initially present as syncope, leading to cognitive decline. Early brain biopsy is crucial for diagnosing unexplained white matter disease and B-cell intravascular lymphoma.

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Area of Science:

Neurology
Oncology
Pathology

Background:

Intravascular lymphoma (IVL) is a rare hematologic malignancy characterized by the proliferation of lymphoid cells within blood vessels.
Clinical presentations of IVL are diverse and often nonspecific, making diagnosis challenging.

Observation:

A 59-year-old woman experienced syncope, followed by subacute cognitive decline culminating in a minimally conscious state.
Despite transfer to a tertiary care center, the patient unfortunately passed away shortly thereafter.

Findings:

Post-mortem brain autopsy confirmed the diagnosis of B-cell intravascular lymphoma.
The findings suggest that syncope may be an initial neurological symptom of central nervous system IVL.

Implications:

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Last Updated: May 19, 2026

Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier

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Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

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Syncope should be considered in the differential diagnosis of unexplained syncope, particularly when other neurological signs emerge.
This case underscores the importance of considering early brain biopsy in patients with unexplained white matter disease to facilitate timely diagnosis of conditions like IVL.