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Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

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Morphoea with myositis: a rare association.

Mary Sommerlad¹, Richard Bull, Claire Gorman

¹Department of Rheumatology, Homerton University Hospital, London E9 6SR, UK.

Case Reports in Rheumatology

|September 1, 2012

Summary

This case study highlights a rare instance of morphoea (localized scleroderma) followed by atypical myositis in a young woman. This previously undescribed association expands our understanding of connective tissue disease presentations.

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Published on: October 31, 2025

Area of Science:

Rheumatology
Dermatology
Immunology

Background:

Morphoea, a form of localized scleroderma, typically presents with skin induration.
Myositis, an inflammatory muscle disease, is often associated with systemic sclerosis.
The co-occurrence of morphoea and myositis is not well-documented in medical literature.

Observation:

A young woman presented with a skin rash characteristic of morphoea, confirmed by biopsy.
Following the morphoea diagnosis, she developed myositis affecting muscles in an unusual pattern.
The distribution of myositis was atypical and not previously associated with localized scleroderma.

Findings:

This case details the first reported instance of myositis developing in the context of morphoea.
The findings suggest a potential, albeit rare, link between localized scleroderma and inflammatory myopathy.
Biopsy confirmed both morphoea and the subsequent myositis.

Implications:

This case expands the spectrum of potential complications associated with morphoea.
It prompts consideration of myositis in patients with morphoea, particularly with atypical symptoms.
Further research may elucidate the underlying mechanisms connecting localized scleroderma and myositis.