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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Related Experiment Video

Updated: May 19, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

TRPC6: an underlying target for human glaucoma.

Qian Fan1, Wen-Bin Huang, Xiu-Lan Zhang

  • 1Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China.

International Journal of Ophthalmology
|September 1, 2012
PubMed
Summary
This summary is machine-generated.

Transient Receptor Potential Canonical 6 (TRPC6) channels may play a role in glaucoma pathogenesis. Targeting TRPC6 could offer a new therapeutic strategy for this leading cause of blindness.

Keywords:
glaucomaneuroprotectiontransient receptor potential canonical 6 channel

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Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
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Published on: April 24, 2020

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Molecular Biology

Background:

  • Glaucoma is a leading cause of irreversible blindness globally.
  • Elevated intraocular pressure is a primary risk factor for glaucomatous damage.
  • Retinal ganglion cell apoptosis is the hallmark of glaucoma, sharing pathogenic links with neurodegenerative diseases like Alzheimer's.

Purpose of the Study:

  • To investigate the potential role of Transient Receptor Potential Canonical 6 (TRPC6) channels in the pathogenesis of human glaucoma.
  • To explore TRPC6 as a potential therapeutic target for glaucoma treatment.

Main Methods:

  • This study focuses on the proposed involvement of TRPC6 channels in neuronal survival, drawing parallels with brain-derived neurotrophic factor.
  • The research investigates the link between TRPC6 and the mechanisms underlying glaucoma and Alzheimer's disease.

Main Results:

  • Recent findings suggest TRPC6 channels, in conjunction with brain-derived neurotrophic factor, may promote neuron survival in both the brain and retina.
  • The study proposes a direct contribution of TRPC6 to the pathological processes observed in human glaucoma.

Conclusions:

  • Transient Receptor Potential Canonical 6 (TRPC6) channels are implicated in the pathogenesis of human glaucoma.
  • TRPC6 presents a promising potential therapeutic target for mitigating glaucomatous neurodegeneration and vision loss.