Related Experiment Video
Updated: May 19, 2026
06:15
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Recurrent orbital schwannomas: clinical course and histopathologic correlation
Michelle Kron1, Brenda L Bohnsack, Steven M Archer
1University of Michigan Medical School, Ann Arbor, MI, USA.
BMC Ophthalmology
|September 4, 2012
Summary
Recurrent orbital schwannomas can occur due to different causes, including orbital schwannomatosis and plexiform schwannoma. Understanding the etiology is crucial for effective treatment and patient counseling.
Area of Science:
- Ophthalmology
- Neurosurgery
- Pathology
Background:
- Schwannomas are slow-growing peripheral glial cell tumors.
- Complete excision is the standard treatment for symptomatic orbital schwannomas.
- Multiple schwannomas may indicate neurofibromatosis type 2 or schwannomatosis.
Observation:
- Two patients with recurrent orbital schwannoma without neurofibromatosis were analyzed.
- A 59-year-old man had two independent recurrent tumors six years post-excision.
- A 5-year-old girl experienced rapid, multiple recurrences after partial excisions.
Findings:
- The man's recurrence suggests isolated orbital schwannomatosis.
- The girl's rapid recurrence correlated with plexiform schwannoma features.
- Each patient's recurrence had a distinct underlying cause.
Implications:
- Orbital schwannomatosis presents unique treatment challenges.
- Accurate diagnosis is vital for appropriate patient management and counseling.
- This study describes the first known case of isolated orbital schwannomatosis.
Related Concept Videos
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
01:19Cushing Syndrome II: Pathophysiology
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...