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Related Experiment Video

Updated: May 19, 2026

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)
08:46

A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)

Published on: March 7, 2017

Diffuse brainstem glioma: prognostic factors.

Marcos Dellaretti1, Nicolas Reyns, Gustavo Touzet

  • 1Department of Neurosurgery, CHRU Hôpital Roger Salengro, Lille, France. mdellaretti@mac.com

Journal of Neurosurgery
|September 4, 2012
PubMed
Summary
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Histological grade is the key prognostic factor for brainstem glioma survival. While MRI findings also show differences, only tumor grade significantly impacts patient outcomes in multivariate analysis.

Area of Science:

  • Neuro-oncology
  • Radiology
  • Pathology

Background:

  • Brainstem gliomas were historically viewed as a uniform entity.
  • Advances in MRI revealed heterogeneity within brainstem gliomas.
  • Certain subgroups exhibit improved long-term survival prognoses.

Purpose of the Study:

  • To retrospectively analyze prognostic factors in histopathologically confirmed brainstem gliomas.
  • To assess the significance of histological grade, patient age, and MRI findings on survival.
  • To identify key predictors of long-term outcomes in brainstem glioma patients.

Main Methods:

  • Evaluation of 100 patients with brainstem glioma (63 adults, 37 children).
  • Histopathological diagnosis and grading of gliomas.

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Last Updated: May 19, 2026

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08:46

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Published on: March 7, 2017

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Published on: February 17, 2023

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  • Analysis of MRI findings, including contrast enhancement patterns.
  • Kaplan-Meier survival analysis and Cox proportional hazards regression.

    • Main Results:

    • Mean survival: 57 months for low-grade vs. 13.8 months for high-grade gliomas (p < 0.001).
    • Mean survival: 54.2 months for non-enhancing vs. 21.7 months for enhancing lesions (p < 0.001).
    • Multivariate analysis identified histological grade as the sole significant prognostic factor (p < 0.001).

    Conclusions:

    • Histological grade and MRI features are significant prognostic indicators for brainstem glioma survival.
    • In multivariate analysis, only histological grade proved to be a significant predictor of patient survival.
    • This highlights the critical role of tumor grading in determining prognosis for brainstem gliomas.