Related Experiment Video
Updated: May 19, 2026

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation
Published on: May 23, 2025
Periorbital area rejuvenation using carbon dioxide therapy
Fioramonti Paolo1, Fallico Nefer, Parisi Paola
1Department of Plastic and Reconstructive Surgery, Sapienza University of Rome, Rome, Italy. fioramontipaolo@hotmail.com
Carboxytherapy effectively treats lower eyelid wrinkles and dark circles. This noninvasive treatment using carbon dioxide (CO2) injections offers a safe and transient solution for periorbital rejuvenation.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Cosmetic Surgery
Background:
- Existing treatments for periorbital rejuvenation have limitations, particularly for the medial lower eyelid.
- There is a need for effective treatments for wrinkles and dark circles in the lower eyelid region.
Purpose of the Study:
- To evaluate the efficacy of carboxytherapy for treating wrinkles and dark circles in the medial and median lower eyelid areas.
- To assess carboxytherapy as a noninvasive rejuvenation method for the periorbital region.
Main Methods:
- 90 patients with moderate to severe periorbital wrinkles or dark circles participated.
- Subcutaneous injections of carbon dioxide (CO2) were administered weekly for 7 weeks.
- Patient outcomes were assessed using photographic documentation and visual analog scales before and after treatment.
Main Results:
- Patients reported significant reductions in fine lines, wrinkles, and periorbital hyperpigmentation.
- Observed side effects were transient and did not necessitate treatment discontinuation.
- Photographic evidence and patient-reported outcomes supported treatment efficacy.
Conclusions:
- Carboxytherapy is an effective noninvasive treatment for periorbital rejuvenation.
- The study demonstrates carboxytherapy's potential for improving lower eyelid wrinkles and dark circles.
- Carbon dioxide therapy offers a promising approach for enhancing the appearance of the eye area.
More Related Videos
03:47Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
Published on: September 27, 2024
10:24Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
Published on: February 12, 2018
Related Concept Videos
Tissue Renewal without Stem Cells
However, failure of such a system...
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment