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Increasing rubella seronegativity despite a compulsory school law.
T R Schum1, D B Nelson, M A Duma
1Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226.
American Journal of Public Health
|January 1, 1990
Summary
Rubella susceptibility increased significantly in children five to seven years post-immunization legislation. Factors like specific immunization timing and inconsistent healthcare access were linked to higher rubella seronegativity.
Area of Science:
- Immunology
- Public Health
- Epidemiology
Background:
- Rubella immunization legislation aimed to reduce susceptibility.
- Persistence of rubella susceptibility post-legislation requires ongoing monitoring.
Purpose of the Study:
- To assess rubella susceptibility in an inner-city school-aged population 5-7 years after immunization laws.
- To identify factors associated with persistent rubella seronegativity.
Main Methods:
- Retrospective review of serologic status in 341 outpatients (1985-1987).
- Analysis of documented immunization status and continuity of care.
- Statistical analysis including odds ratios and confidence intervals.
Main Results:
- Overall rubella seronegative rate was 17%, increasing from 4.2% to 24.5% during the study.
- Seronegativity was higher in patients with unknown immunization status (19%) vs. documented (13%).
- Lack of continuity of care (≤2 years) and immunization in 1977/1978 were associated with increased seronegativity.
Conclusions:
- Rubella susceptibility remained a concern years after immunization mandates.
- Continuity of care and specific immunization timing appear to influence serologic protection.
- Further research is needed to explain the observed increase in rubella seronegativity.
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