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A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue

Published on: November 11, 2022

Multiscale model predicts tissue-level failure from collagen fiber-level damage.

Mohammad F Hadi¹, Edward A Sander, Victor H Barocas

¹Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA. hadix004@umn.edu

Journal of Biomechanical Engineering

|September 4, 2012

Summary

A new multiscale mechanical model predicts soft tissue failure by linking individual collagen fiber damage to overall material response. This computational tool aids in understanding and predicting failure in biological and engineered tissues.

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Published on: October 28, 2013

Area of Science:

Biomaterials Science
Mechanical Engineering
Tissue Engineering

Background:

Soft tissues, particularly collagenous ones, are susceptible to damage from excessive forces due to complex, multiscale physical processes.
Understanding the failure mechanisms at both microstructural and macroscale levels is crucial for tissue repair and engineering.

Purpose of the Study:

To develop and validate a multiscale mechanical model for predicting the failure of collagenous soft tissues.
To investigate the relationship between discrete collagen fiber failure and the overall macroscopic mechanical response of the tissue.

Main Methods:

A multiscale mechanical model was developed, incorporating spatial heterogeneity and linking discrete collagen fiber failure to tissue material response.
The model was calibrated and validated using experimental failure data from type I collagen gels of varying geometries.

Main Results:

The model successfully predicted the mechanical response and failure behavior of type I collagen gels.
Results demonstrated that micrometer-scale fiber failure rules significantly influence the millimeter-scale macroscopic failure response.

Conclusions:

The proposed multiscale model offers a valuable tool for predicting the failure conditions of soft tissues and engineered tissue analogs.
This framework can be applied to study failure mechanisms in other complex, fiber-based mechanical systems.