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Outcomes after surgery for spinal metastatic leiomyosarcoma
John E Ziewacz1, Darryl Lau, Frank La Marca
1Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan 48109-5338, USA.
Journal of Neurosurgery. Spine
|September 4, 2012
Summary
Surgical intervention for spinal metastatic leiomyosarcoma, a rare cancer, can improve neurological function and relieve pain. Aggressive management is recommended for selected patients due to potential for prolonged survival.
Area of Science:
- Oncology
- Neurosurgery
- Orthopedic Oncology
Background:
- Leiomyosarcoma is a rare smooth-muscle sarcoma.
- Spinal metastasis from leiomyosarcoma is uncommon.
- Clinical course and survival vary in metastatic leiomyosarcoma.
Purpose of the Study:
- To report single-institution experience in surgical treatment of spinal metastatic leiomyosarcoma.
- To analyze clinical management and outcomes.
- To review current literature on the topic.
Main Methods:
- Retrospective review of electronic medical records.
- Analysis of surgical intervention for metastatic leiomyosarcoma of the spine.
- Review of existing literature.
Main Results:
- Eight patients underwent surgical management for spinal metastatic leiomyosarcoma.
- 75% showed improvement in Nurick grade, with significant pain relief.
- 5 patients experienced recurrence, requiring repeat surgery; mean survival was 11.7 months.
Conclusions:
- Spinal metastasis of leiomyosarcoma is rare.
- Surgical intervention can improve pain and neurological function.
- Aggressive management may be beneficial for well-selected patients given potential for prolonged survival.