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Updated: May 19, 2026
05:52
Observation and Analysis of Blinking Surface-enhanced Raman Scattering
Published on: January 11, 2018
Multiplex optical sensing with surface-enhanced Raman scattering: a critical review
Laura Rodriguez-Lorenzo1, Laura Fabris, Ramon A Alvarez-Puebla
1Departamento de Química Física, Universidade de Vigo, Spain.
Analytica Chimica Acta
|September 4, 2012
Summary
Multiplex analysis using surface-enhanced Raman scattering (SERS) enables rapid, ultrasensitive detection of multiple targets simultaneously. Recent advances focus on direct methods, functionalized nanoparticles, and encoded particles for diverse applications.
Area of Science:
- Analytical Chemistry
- Spectroscopy
- Nanotechnology
Background:
- Multiplex analysis allows simultaneous detection of multiple targets for efficient diagnostics.
- Surface-enhanced Raman scattering (SERS) offers ultrasensitive detection with unique molecular signatures.
- SERS is suitable for complex environments like biological fluids.
Purpose of the Study:
- To review recent advancements in multiplex SERS techniques.
- To highlight the advantages of SERS for multiplexed detection.
- To discuss different strategies for implementing multiplex SERS.
Main Methods:
- Review of direct multiplex SERS methods.
- Analysis of SERS techniques utilizing functionalized plasmonic nanoparticles.
- Examination of SERS-encoded particles for multiplexing.
Main Results:
- Multiplex SERS provides rapid and accurate diagnostics.
- Ultrasensitive detection is achieved with reduced deconvolution times.
- SERS is adaptable to demanding environmental conditions.
Conclusions:
- Multiplex SERS is a powerful tool for simultaneous analysis.
- Advancements in nanoparticle functionalization and encoded particles enhance SERS capabilities.
- SERS holds significant potential for diagnostics in various fields.
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