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Inv(14)(q11q32) in one of four different clones in a case of angioimmunoblastic lymphadenopathy
B Schlegelberger1, A Feller, A Himmler
1Department of Human Genetics, Christian Albrecht University, Kiel, Federal Republic of Germany.
Cancer Genetics and Cytogenetics
|January 1, 1990
Abstract:
A case of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) with four cytogenetically different cell clones (49,XX,+5,+19,+21/47,XX,+X/46,XX,inv (14)(q11q32)/45,X,-X) is reported. To our knowledge, this is the first case of AILD with an inv(14)(q11q32), thus probably involving the T-cell receptor alpha-chain gene. The cytogenetic findings are discussed with respect to the possible progression of AILD to malignant lymphoma.