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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Updated: May 19, 2026

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

Published on: July 3, 2014

Animal models.

Antonietta Coppola¹, Solomon L Moshé

¹Saul R. Korey Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.

Handbook of Clinical Neurology

|September 4, 2012

Summary

This summary is machine-generated.

Animal models are crucial for understanding epilepsy, aiding research from basic science to clinical applications. This review highlights various models, emphasizing rodents and developmental aspects, to advance epilepsy treatment and prevention strategies.

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The Bovine Lung in Biomedical Research: Visually Guided Bronchoscopy, Intrabronchial Inoculation and In Vivo Sampling Techniques

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Animal Model of Implant-Associated Infections in Mice

Animal Model of Implant-Associated Infections in Mice

Published on: June 27, 2025

Area of Science:

Neuroscience
Pharmacology
Genetics

Background:

Epilepsy represents a significant global disease burden, necessitating robust research.
Animal models are indispensable tools for elucidating epilepsy pathophysiology and treatment strategies.
Understanding developmental aspects of epilepsy is critical, as it often differs from adult presentations.

Purpose of the Study:

To provide a comprehensive overview of in vitro and in vivo animal models for epilepsy research.
To emphasize the application of these models in understanding epileptogenesis and various epilepsy syndromes.
To highlight the role of animal models in advancing research on developmental epilepsies.

Main Methods:

Discussion of electrical stimulation and chemical-induced seizure models.
Detailed review of kindling models for epileptogenesis research.
Exploration of acquired focal models, absence epilepsy models, infantile spasms models, and genetic models.

Main Results:

Animal models, particularly in rodents, have significantly contributed to understanding epilepsy.
Various models, including kindling and genetic models, mimic different aspects of human epilepsies.
Developmental aspects of epilepsy are effectively studied using specific animal models.

Conclusions:

Animal models are fundamental to epilepsy research, offering insights into pathophysiology and treatment.
Continued development of novel animal models is essential for discovering new therapeutic strategies.
Optimizing animal models will accelerate the translation of scientific findings to clinical practice for epilepsy prevention and cure.